An interesting case of Langerhans cell histiocytosis
How to cite this article: Kazi BS. An interesting case of Langerhans cell histiocytosis. J Hematol Allied Sci 2021;1:122-3.
A 23-year-old girl presented with complaints of bone pains, recurrent fractures for 3 years of age, bilateral neck swelling for 8 years, and abdominal pain for 1 year. She denies any constitutional symptoms. On examination, there were no organomegaly and bleeding stigmata. Her CBC profile was absolutely normal. Her radiograph of B/L hip joint [Figure 1] revealed multiple punched-out lytic lesions with sclerosed margins and fracture left shaft femur. CECT of the abdomen [Figure 2] revealed a spleen of normal size with multiple hypodense lesions ranging from 1 to 10 mm in size. The visible axial skeleton including spine, ribs, hip bones, and B/l proximal femur showed multiple punched-out lytic lesions with sclerosed margins. The CT-guided biopsy of the osteolytic lesion was consistent with Langerhans cells histiocytosis corroborated by IHC staining for CD1a, CD207, and S100.
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