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Residents’ Corner
2 (
1
); 21-21
doi:
10.25259/JHAS_17_2022

Cyclosporine-induced hirsutism

Department of Hematology, NRSMCH, Kolkata, West Bengal, India
Corresponding author: Abhishek Kumar, Department of Hematology, NRSMCH, Kolkata, West Bengal, India. dr.kr.abhishek07@gmail.com
Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Kumar A. Cyclosporine-induced hirsutism. J Hematol Allied Sci 2022;2:21.

A 35-year-old lady, a case of non-severe aplastic anemia diagnosed in June 2020, was treated with cyclosporine A at a dose of 5 mg/kg/day in two divided doses; achieved partial response at 9 months and continued. After 1 year, the dose of cyclosporine A was reduced to 3 mg/kg/day in two divided doses. The patient was doing well but after 18 months of cyclosporine A therapy, she noticed that there was an excess terminal hair growth over the side lock [Figure 1], upper lip [Figure 2], chin, and midsternum which affected her mood and social behavior and she isolated herself socially. The Ferriman– Gallwey hirsutism score was 10; a score of 8 or higher is regarded as indicative of androgen excess.[1] The incidence of hirsutism following cyclosporine A therapy is around 5%.[2] Cyclosporine A was tapered off gradually with other supportive care continued. The physicians must counsel and take care of this not-so-uncommon side effect of cyclosporine A that may compromise the quality of life of a patient.

Figure 1:: Excess terminal hair growth over side lock.
Figure 2:: Excess terminal hair growth over upper lip

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

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  2. . Efficacy and safety of tacrolimus compared with cyclosporine microemulsion in renal transplantation: A randomized multicentre study. Lancet. 2002;359:741-6.
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